J&J’s booster shot provides strong protection against severe disease from Omicron, a study says.


A Johnson & Johnson booster shot supplied strong protection against the Omicron variant, significantly decreasing the danger of hospitalization, in line with a scientific trial in South Africa.

The study, which in contrast greater than 69,000 boosted well being care staff with a corresponding group of unvaccinated South Africans, discovered that two pictures of the vaccine diminished the danger of hospitalization from Omicron by about 85 p.c. In comparability, one other study in South Africa discovered that two pictures of the Pfizer-BioNTech vaccine diminished the danger of hospitalization by about 70 percent.

Although the U.S. Food and Drug Administration has approved the Johnson & Johnson vaccine as a booster shot, the Centers for Disease Control and Prevention advisable that different vaccines be most well-liked. The C.D.C. raised considerations about rare but life-threatening blood clots which were linked to the Johnson & Johnson vaccine.

But the authors of the brand new study, which was revealed on a preprint server and has not but been peer-reviewed, mentioned that the outcomes had been necessary for vaccination efforts in Africa, the place the Johnson & Johnson vaccine is a mainstay of Covid public well being efforts. As the continent braces for a wave of Omicron instances, a second dose of the vaccine may forestall a surge of hospitalizations.

In a completely different scientific trial that led to September, when Delta was nonetheless the dominant variant worldwide, Johnson & Johnson discovered that a second dose of its vaccine given eight weeks after the primary greatly increased its efficacy. In the U.S. arm of the trial, efficacy against delicate to severe Covid-19 rose to 94 p.c, in contrast with 74 p.c for one shot. Across trial websites in 10 nations, the vaccine protected all volunteers against severe disease.

Those outcomes prompted South Africa to launch a trial in November amongst well being care staff who had already acquired one dose of the vaccine between six and 9 months earlier. When the Omicron variant started surging throughout South Africa in late November, the researchers working the trial started monitoring how boosted well being care staff fared against the variant, discovering that it labored effectively.

This consequence was considerably shocking, provided that antibodies taken from individuals who had acquired one dose of the vaccine failed to dam Omicron from infecting cells in laboratory experiments.

It’s potential that the booster pictures raised antibodies to protecting ranges. And whereas antibodies assist the physique fend off infections, they’re simply one in all many components of the immune system.

Certain immune cells assist combat Covid by attacking virus-infected cells. In a study posted online on Tuesday, South African researchers discovered that immune cells taken from individuals who acquired Johnson & Johnson vaccines acknowledged Omicron-infected cells virtually in addition to they acknowledged cells contaminated with different variants.

It’s potential that along with elevating antibodies, Johnson & Johnson booster pictures additionally improve the military of immune cells that may wage conflict on Omicron.



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